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KMID : 0358419940370091808
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Korean Journal of Obstetrics and Gynecology
1994 Volume.37 No. 9 p.1808 ~ p.1820
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Human Papilomavirus Infection and the Risk for Cervical Cancer in Korea
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이효표
송용상/박창수/박노현/강순범/김동현/유근영/박순희
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Abstract
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The purpose of this study is to determine the risk of developing cervical cancer in patients with human papillomavirus (HPV) infection and to investigate the risk factors for the cervical cancer in Korean women. The polymerase chain reaction(PCR)
was
used to detect HPV DNA and a case-control study was performed in 96 patients with histologically confirmed invasive carvical cancer and 653 hospital control for routine annual gynecologic examination Information on sexual behavior and other risk
factors
was obtained by interview. Overall, the prevalence of HPV infection was 61.1% in patients with cervical cancer, while for HPV 16/18 it was 33.9%. Those positive. For all HPV had a odds ratio(OR) of 4.7 (95% confidence interval: 2.5~8.7), and
those
positive for HPV 16/18 had a OR of 9.3 (95% CI: 4.7~18.7). There were statistically significant increases in risk of developing cervical cancer in Korean women with several factors, including low educational status, late first Pap smear, small
number of
Pap smear, abnormal marital status. Smoking cigarettes, and uncircumcised husband. These results indicate that there is a very strong association between HPV infection and invasive cervical cancer and several risk factors also have some
association.
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KEYWORD
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